This is a proposal for the existence of a "minimal cancer cell" that would result from the evolutionary dynamics of unstable tumors. The idea is that genomic instability in cancer has an upper limit that might involve a "minimal" genome complement that we should be able to characterize as a network. What is the nature of this network? That's what we try to conjecture.

This work has been performed by researchers of R. Solé Lab.

Reference article: Solé et al. 2014.Can a minimal replicating construct be identified as the embodiment of cancer? Bioessays, 35 (5), 503-512. DOI 10.1002/bies.201300098

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