The Institute of Evolutionary Biology seeks a: Postdoctoral researcher

Application deadline: 10th January 2025 

Reference: Postdoctoral researcher

More information:  

The Mutation Dynamics lab is part of the Evolutionary Medical Genomics Program, a collaborative initiative by the IBE, UPF, and CRG.

Project Overview: Characterizing the DNA damage response across primates How do long-lived species maintain lower mutation rates and minimize the impacts of DNA damage over time? This project aims to uncover the molecular mechanisms that have evolved to protect cells from DNA damage and reduce mutational burden in species with diverse life histories.

Using primary fibroblast cell lines from diverse mammalian species, we aim to systematically compare their cellular responses to controlled mutagen exposure. By measuring changes in mutation rates, gene expression, chromatin accessibility, and cell viability, the project seeks to:

• Identify core pathways that mitigate DNA damage and reduce mutation accumulation.
• Reveal how evolutionary adaptations enable longer-lived species to maintain genome integrity over time.
• Provide new insights into the molecular underpinnings of cancer resistance and longevity.

This project will be supported by a lab technician to run the experiments. It will combine experimental assays with cutting-edge genomics to deepen our understanding of the DNA damage response in mammals, with implications for evolutionary biology, aging, and disease.

Interested candidates should complete the application form and include a CV, a brief motivation letter explaining their interest in the project, contact information for at least two referees, and details on how they learned about this job offer. For questions, please contact Marc de Manuel at [email protected].